The Exchange Rate of the Thiol Ligand of iPr3PAuSATg With the Cys-34 Residue of Bovine Serum Albumin
نویسندگان
چکیده
Auranofin [Et3PAuSATg
منابع مشابه
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2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogenic heterocyclic aromatic amine formed during the combustion of tobacco. AαC undergoes bioactivation to form electrophilic N-oxidized metabolites that react with DNA to form adducts, which can lead to mutations. Many genotoxicants and toxic electrophiles react with human serum albumin (albumin); however, the chemistry of reactivity of AαC with ...
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The first detailed kinetic study of in vitro reactions between serum albumin and the secondgeneration gold drug Auranofin [Et3PAuSATg triethylphosphine-(2,3,4,6-tetra-O-acetyl-l-8-Dglucopytanosato-S-) gold(I)] and its tri-i-propylphosphine analogue, .iPr3PAuSATg, are reported. The reactions were investigated using Penefsky spun columns and NMR saturation transfer kinetics. Based on the Penefsky...
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عنوان ژورنال:
- Metal-Based Drugs
دوره 1 شماره
صفحات -
تاریخ انتشار 1994